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The Adiponectin Receptor Agonist, ALY688: A Promising Therapeutic for Fibrosis in the Dystrophic Muscle.

Dubuisson N, Versele R, Davis-López de Carrizosa MA, Selvais CM, Noel L, Planchon C, Van den Bergh PYK, Brichard SM, Abou-Samra M.

Cells. 2023 Aug 19;12(16):2101

ALY688 elicits adiponectin-mimetic signaling and improves insulin action in skeletal muscle cells. 

Sung HK, Mitchell PL, Gross S, Marette A, Sweeney G.

Am J Physiol Cell Physiol. 2022;322(2):C151-C163.


Memory impairment in the D2.mdx mouse model of Duchenne muscular dystrophy is prevented by the adiponectin receptor agonist ALY688. 

Bellissimo, C. A., Castellani, L. N., Finch, M. S., Murugathasan, M., Gandhi, S., Sweeney, G., Abdul-Sater, A. A., MacPherson, R. E. K., & Perry, C. G. R.

Experimental Physiology, 108, 1108–1117  (2023). 

Effects of the adiponectin mimetic compound ALY688 on glucose and fat metabolism in visceral and subcutaneous rat adipocytes. 

Da Eira D, Jani S, Sung H, Sweeney G, Ceddia RB.

Adipocyte. 2020;9(1):550-562

Adiponectin agonist ADP355 attenuates CCl4-induced liver fibrosis in mice.

Kumar P, Smith T, Rahman K, Thorn NE, Anania FA.

PLoS One. 2014 Oct 13;9(10):e110405.

Adiponectin-derived active peptide ADP355 exerts anti-inflammatory and anti-fibrotic activities in thioacetamide-induced liver injury.

Wang H, Zhang H, Zhang Z, Huang B, Cheng X, Wang D, la Gahu Z, Xue Z, Da Y, Li D, Yao Z, Gao F, Xu A, Zhang R.

Sci Rep. 2016 Jan 18;6:19445.

The Wound Healing Effects of Adiponectin Eye Drops after Corneal Alkali Burn.

Li Z, Cui L, Yang JM, Lee HS, Choi JS, Woo JM, Lim SK, Yoon KC.

Curr Eye Res. 2016 Nov;41(11):1424-1432

Therapeutic Effect of Topical Adiponectin-Derived Short Peptides Compared with Globular Adiponectin in Experimental Dry Eye and Alkali Burn.

Li YJin R1, Li LHsu HHYou ICYoon HJYoon KC.

J Ocul Pharmacol Ther. 2019 Oct 30.




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