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Adiponectin in Ocular Diseases:

1.) Therapeutic effect of topical adiponectin in a mouse model of desiccating stress-induced dry eye.

Li Z, Woo JM, Chung SW, Kwon MY, Choi JS, Oh HJ, Yoon KC.

Invest Ophthalmol Vis Sci. 2013 Jan 7;54(1):155-62.

2.) The Wound Healing Effects of Adiponectin Eye Drops after Corneal Alkali Burn.

Li Z, Cui L, Yang JM, Lee HS, Choi JS, Woo JM, Lim SK, Yoon KC.

Curr Eye Res. 2016 Nov;41(11):1424-1432

3.) Therapeutic Effect of Topical Adiponectin-Derived Short Peptides Compared with Globular Adiponectin in Experimental Dry Eye and Alkali Burn.

Li YJin R1, Li LHsu HHYou ICYoon HJYoon KC.

J Ocul Pharmacol Ther. 2019 Oct 30.


Adiponectin Peptidomimetic Chemistry


3.) Design and development of a peptide-based adiponectin receptor agonist for cancer treatment.

Otvos L Jr, Haspinger E, La Russa F, Maspero F, Graziano P, Kovalszky I, Lovas S, Nama K, Hoffmann R, Knappe D, Cassone M, Wade J, Surmacz E.

BMC Biotechnol. 2011 Oct 5;11:90. doi: 10.1186/1472-6750-11-90.


4.) Development of second generation peptides modulating cellular adiponectin receptor responses.

Otvos L Jr, Knappe D, Hoffmann R, Kovalszky I, Olah J, Hewitson TD, Stawikowska R, Stawikowski M, Cudic P, Lin F, Wade JD, Surmacz E, Lovas S.

Front Chem. 2014 Oct 17;2:93.


5.) Optimization of adiponectin-derived peptides for inhibition of cancer cell growth and signaling.

Otvos L Jr, Kovalszky I, Olah J, Coroniti R, Knappe D, Nollmann FI, Hoffmann R, Wade JD, Lovas S, Surmacz E.

Biopolymers. 2015 May;104(3):156-66.


ALY688 Effects in Models of Fibrosis

6.) Adiponectin agonist ADP355 attenuates CCl4-induced liver fibrosis in mice.

Kumar P, Smith T, Rahman K, Thorn NE, Anania FA.

PLoS One. 2014 Oct 13;9(10):e110405.

7.) Adiponectin-derived active peptide ADP355 exerts anti-inflammatory and anti-fibrotic activities in thioacetamide-induced liver injury.

Wang H, Zhang H, Zhang Z, Huang B, Cheng X, Wang D, la Gahu Z, Xue Z, Da Y, Li D, Yao Z, Gao F, Xu A, Zhang R.

Sci Rep. 2016 Jan 18;6:19445.


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